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Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study of adults with obesity or overweight. Diabetes, Obesity and Metabolism

These signaling pathways may be related to the other results, such as the reduction of the production of chemokines and pro-inflammatory cytokines, such as IL-6, TGF-, and TNF- in TH cells, as well as the expression of adhesin (CD11b) and chemokines, such as CCL-2 (MCP-1) in monocytes (He et al., 2013

Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes

I hadnt even worked my way up to a therapeutic dose yet, but I could feel the tides shifting

WHO (2025)