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Melatonin reduces hypoxic-ischaemic (HI) induced autophagy and apoptosis: an in vivo and in vitro investigation in experimental models of neonatal HI brain injury

12 Reduced GSH is capable of directly scavenging radicals and peroxides by being oxidized to either GSSG or to a mixed disulfide, thereby preventing cell membrane lipid peroxidation and its subsequent deleterious effects on cellular functions

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Disrupted copper homeostasis contributes to numerous neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), making GHK-Cu's copper-regulating properties particularly relevant to neurological research

Since rapamycin treatment inhibits the alteration of PIP 3 and PTEN levels under insulin-resistant conditions, it is believed that the mTORC1 is involved in negatively regulating the IRS-1/PI3K/AKT signaling cascade downstream of the insulin receptor