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doi: 10.1128/aac.39.7.1398 284 MukherjeeJ.PirofskiL

CJC-1295 is a synthetic analogue of Growth Hormone-Releasing Hormone (GHRH) with tetrasubstituted modifications (D-Ala, Gln, Ala, Leu) that protect the peptide from degradation by the enzyme DPP-IV, thereby extending its half-life relative to native GHRH

Fiber slows gastric emptying and provides substrate for beneficial gut bacteria, which produce short-chain fatty acids (SCFAs) that may stimulate L-cells

One important consideration is that many psychiatric medications used to treat bipolar disorder can cause significant weight gain and metabolic complications

The first GLP-1 agonistsintended to treat T2Dcame onto the market almost two decades ago