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Although several laboratory and animal studies suggest potential regenerative effects, there are scant high-quality randomized controlled human trials demonstrating its safety or efficacy

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This is characterized, for example, by the changes in dendrites, synapses, neurogenesis, and astrogliosis, as well as the upregulation of growth-promoting genes and proteins ( Transfer to a stimulus-rich environment, containing for example, running wheels, tunnel systems or climbing possibilities represents a well-established model for modulating cellular and structural plasticity ( + progenitor cells in the striatum in the peri-infarct region (Venna et al., 2014