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A 2022 stability study in the Journal of Pharmaceutical and Biomedical Analysis found that semaglutide stored outside recommended temperature ranges lost approximately 8-15% potency per month

Clinical practice guideline for diseases subject to mass screening of newborns 2019

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In Conclusion Until there is more evidence-based research on the impact of GLC-1 receptor agonists on anesthesia, specifically conscious sedation, DOCS Education recommends a medical consult with the patients PCP or endocrinologist, and absent the strong recommendation to the contrary from their prescribing physician, have the patient withhold their weekly injectable GLP-1 receptor antagonist one week before sedation, and their daily GLP-1 receptor agonist on the day of the sedation appointment, and be NPO 6 hours before the appointment as usual