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Comparison and Clinical Implications Final Verdict: Platelet-Rich Plasma is a Validated Treatment, While Peptide Therapy Requires Further Research While peptide injections show promise in preclinical studies, their role in musculoskeletal treatment remains experimental , with a lack of well-controlled human trials to confirm their efficacy

Additionally, vitamin B12 supplementation has been shown to reduce tissue necrosis and inflammation caused by methotrexate toxicity [150]

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Research indicates it is a potent regulator of lipid metabolism and cartilage regeneration without stimulating IGF-1 or inducing hyperglycemia

These include [6, 34, 39]: Irritation at the site of injection Fatigue Nausea Light-headedness Sweatin g Adverse effects are often attributable to low-grade peptides