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Fructose significantly increases GIP secretion in streptozotocin-treated, hyperglycemic mice in a K ATP -dependent manner (Seino et al., 2015) and in ob/ob mice (Flatt et al., 1989)

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Non-targeted analyses UHPLC-ESI-QTOFMS analyses Urine samples and medium samples from the in vitro liver models and the enteric bacteria were analyzed using HRMS-based non-targeted methods as described in David et al