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This effect was mediated via adenylate cyclase (AC) / PKA signaling pathway, as it was abolished by the GLP-1R inhibitor exendin-9, or by PKA inhibitors SQ22536 and H89 [58]

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Compared to placebo, the mean change in FPG with saxagliptin was 12 mg/dL in the subgroup of patients with moderate renal impairment, 4 mg/dL in the subgroup of patients with severe renal impairment, and +44 mg/dL in the subgroup of patients with ESRD