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This sulfonamide ( 41 ) demonstrates a high metabolic stability and alters dendritic spine morphology and increases spine density in primary cultures of hippocampal neurons ( Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Figure 10)

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Investigations focus on cell health proxies rather than clinical outcomes

Neuroprotective effects of zonisamide target astrocyte

Recent studies have implicated the gut microbiota in many brain conditions, including anxiety, autism, Alzheimers disease, schizophrenia, and Parkinsons disease