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10.1373/clinchem.2010.156901 97 MallickH.MaS.FranzosaE

That extra volume is what builds the muscle The phosphocreatine system is especially concentrated in the frontal brain areas involved in working memory and strategic planning The brain makes its own creatine but muscles are greedy for it when you train, so dietary creatine often gets mopped up before reaching the brain At 10 grams a day a German study found via MRI that brain creatine levels increase above what the brain makes on its own

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Eur J Prev Cardiol 26(2_suppl):2532 Powell-Wiley TM, Poirier P, Burke LE et al (2021) Obesity and cardiovascular disease: a scientific statement from the American Heart Association