Numerous studies have revealed that aberrant pathways, including transforming growth factor-/Smad (TGF-/Smad), Wnt/-catenin, inhibition of kappa B (IB)/nuclear factor kappa B (NF-B), and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2), are involved in renal fibrosis [23, 26, 27]
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An unrelated peptide without a human protein correlate previously isolated from HLA-C*06:02 of lymphoblastoid B cells ( Measurement of stimulation-induced [ 3 H]-thymidine incorporation of PBMC and induction of CD137 expression on CD8 + T cells To measure stimulation-induced proliferation, triplicates of PBMC cells were pulsed overnight on day 5 of stimulation with 24,500 bq/well [ 3 H]-thymidine (Hartmann Analytic (Braunschweig, Germany), and proliferation was assessed according to the incorporated radioactivity