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*This estimate derives from Eli Lillys SURMOUNT-4 clinical trial results which showed 20% average weight loss over 36 weeks among people utilized a maximum tolerated dose of 10 mg or 15 mg once-weekly

9C), suggesting that the microbiota may regulate intramuscular fat content through both positive and negative mechanisms

Not recommended during pregnancy or breastfeeding unless advised by a healthcare professional

Losing 5% to 10% of body weight can make a big difference

This is of interest as RegIII has been suggested to modulate microbiota through spatial segregation, thereby preventing commensal microbiota from reaching the epithelium (124, 146, 147)