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Key findings: Deprescribing interventions significantly reduced the use of potentially inappropriate medications (PIMs) and other targeted medications

Cathelicidins modulate TLR-activation and inflammation

Some doctors will give antibiotic drops prior to the injection

This program may be appropriate for individuals who struggle with persistent weight gain, appetite control, metabolic resistance, or those who have not achieved results through diet and exercise alone

Notably, based on the results from part 1 of the ESSENCE trial, on 15 August 2025, the FDA approved semaglutide 2.4 mg for the treatment of adults with MASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis)