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Pharmacokinetic studies conducted at Washington State University demonstrated that dihexa achieves peak plasma concentration within 30 to 60 minutes of subcutaneous administration, followed by logarithmic decay with a calculated half life of 2.5 hours in rodent models

2003;53(suppl 3):S2636

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As the primary source of inflammatory factors in the liver, activated Kupffer cells release large amounts of inflammatory factors such as TNF-, IL-1, and IL-6, leading to cascading amplification of inflammatory signals, thereby inducing hepatocyte apoptosis and necrosis