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Because epithelial cells may also develop copy number alterations (CNA) when expanded ex vivo 56 , we performed whole-genome sequencing, finding only a subpopulation of cells (1729%) with detectable CNA after 8 months in continuous culture, mostly amplifications affecting chromosome 10 (Fig

5-hydroxytryptamine in migraine: the puzzling role of ionotropic 5-HT3 receptor in the context of established therapeutic effect of metabotropic 5-HT1 subtypes

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To identify mechanisms directly affected by Gsta4/4-HNE, we analyzed RNA-seq data of corpus callosum-derived O4 + OLs to identify crucial molecules involved in these processes, using the following criteria: (1) significant differential expression ( P 0.001) between DA Wt and DA Gsta4 (Supplementary Data 2)