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6-8 In vitro and animal model studies have examined GHK-Cu's effects on collagen synthesis markers and osteoblast attachment in bone cell models

However, the discovery of functional extrinsic death receptor-mediated eryptosis and necroptosis of erythrocytes associated with the necrosome formation opens new horizons for our understanding of the possible role of caspases in mature erythrocytes, since caspase-8 might be involved in coordinating the cell fate of mature erythrocytes