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These distinct mechanismstirzepatide's incretin-based glucose and appetite regulation versus sermorelin's growth hormone axis stimulationtheoretically address different aspects of metabolic health without direct pharmacological overlap

Given the systematic differences in historical MIPS performance of likely ASM participants in small practices that we observed and discuss in section III.C.2.e.(4) of this final rule, reducing the ASM risk level for ASM participants in small practices would be one way to prevent them from being unfairly penalized in their payment adjustments

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