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Triagonist-treated mice showed a slight reduction of body weight along treatment (2%) and improved glucose tolerance, although no changes were detected in the other metabolic parameters analyzed (Fig

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Compatibility of drug with the propellant and the metal canister and actuator, solubility or suspendability of drug in the propellant, possibility of nozzle obstruction, and very advanced design of the device are other concerns that may be challenging [11]