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Improvements in blood glucose control The clinical trials have shown that retatrutide treatment can lead to significant improvements in glycemic control, as evidenced by reductions in glycated haemoglobin (HbA1c) levels

Semaglutide works by mimicking the action of the GLP-1 hormone, which regulates appetite and food intake

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A recent study by Gabery et al, 139 using Semaglutide, revealed that GLP-1RAs could directly access multiple brain nuclei, including the brainstem, septal nucleus, and hypothalamus, but did not cross the BBB

Acknowledgements This work was funded by the DFG grant DE 1431/20-1 to M.D