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3.3 Immune system enhancement The natural substances can act as immune checkpoint and co-inhibitory modulators, some polyphenols decrease the expression of tissue-and tumoural PD-L1 or of CTLA-4 on T cells giving a mechanistic reasoning to combination with nutritional support in patients treated with check point inhibitors, eventually reversing acquired resistance to treatment or decreasing the effective dose for drug administration (193)

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(1984) [15], using enzyme immunoassay after intravenous administration, measured plasma half-lives of 4.0 0.7 minutes in dogs, 2.9 minutes in one monkey, and 2.0 0.54 minutes in rats

J Am Acad Child Adolesc Psychiatry, 2007