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Most perceived tolerance issues stem from misunderstanding the normal trajectory of pharmaceutical weight loss rather than any actual reduction in drug effectiveness

They work by mimicking the behavior of Glucagon-Like Peptide 1, a naturally occurring hormone that triggers the pancreas to release insulin, slow digestion and reduce appetite and hunger

Mateos M-V, Blad J, Bringhen S, Ocio EM, Efebera Y, Pour L, Gay F, Sonneveld P, Gullbo J et al (2020) Melflufen: a peptidedrug conjugate for the treatment of multiple myeloma

Statistical Analysis Each experiment was performed at least three times

The dose schedule is designed to be flexible, and staying at a lower maintenance dose is always preferable to abandoning the protocol entirely