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In rabies virus G protein, two modalities of neutralization were described: (1) targeting an epitope on a single domain that is fully accessible only in prefusion is enough to lock the protein in prefusion conformation, hence inhibiting the fusion process 44 and (2) recognition of an epitope that spans more than three domains, including one on an adjacent protomer, prevents the conformational changes required for fusion 45

None of these options were ever discussed in the cancer pamphlets

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Instead, doctors who treat obesity, and the serious health risks that come with it, fear the medications are making this health disparity worse