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Treatment with the multi-agonists caused a very significant reduction in body weight during the 72-h treatment period, which was more pronounced in mice treated with GLP1/GIP/Glucagon (Fig
doi: 10.4081/or.2010.e23 24
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Self-reported community protocols commonly describe once-daily dosing with on/off cycling, motivated partly by the absence of any long-term human safety data and partly by a community perception of diminishing returns or tolerance over continued use
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