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A retrospective study conducted at the University Health Network found that, in liver transplant recipients with diabetes, combination therapy reduced HbA1c and alanine aminotransferase levels more effectively than DPP-4 inhibitors. Additionally, two clinical trials in patients with Type 2 diabetes demonstrated that combination therapy significantly lowered HbA1c by 1.34% and 1.21%, compared to a 0.54% reduction with placebo, starting from a baseline of 8.0%. These findings suggest that combination therapy may be especially beneficial in the liver transplant population, where patients often experience weight gain and develop metabolic co-morbidities

In addition, cross-sectional dietary analyses suggest that GLP-1RA therapy can reduce nutrient intake in ways that may affect protein and micronutrient sufficiency [75]

Medicaid is a joint federal-state funded program that mostly serves people with lower incomes under the age of 65 or who have a disability

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This study was further funded by the French National Research Agency (ANR-10-LABX-46 [European Genomics Institute for Diabetes]) to A.B