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Others require careful medical supervision that goes beyond standard care

An improved understanding of the mechanisms underlying glucose-lowering by metformin would provide the potential to refine its clinical application in the management of type 2 diabetes

However, it was further noted that these savings are far outweighed by the $6,540 average annual drug cost for GLP1 therapy, making the shortterm return on investment (ROI) negative for most employers

doi: 10.1111/j.1365-2982.2009.01422.x