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In December 2025, Nektar Therapeutics reported topline data from its Phase 2b REZOLVE-AA trial evaluating rezpegaldesleukin in patients with severe-to-very-severe AA

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Lee's team found that over the three years of the study, GLP-1 prescriptions among people ages 12 to 25 jumped by more than 594% (equivalent to a nearly sevenfold rise)