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products may contain contaminants, adulterants, or unlisted substances Allergic reactions : Adhesive components and botanical extracts can cause contact dermatitis, skin irritation, or systemic allergic responses Drug interactions : Herbal ingredients may interact with prescription medications, including anticoagulants, antihypertensives, or diabetes medications False reassurance : Belief in patch efficacy may lead patients to neglect dietary modifications, physical activity, or medication adherence The financial burden represents another limitation

No evidence shows these products produce clinically meaningful metabolic effects or significant changes in endogenous GLP-1 levels

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The American Diabetes Association and American College of Physicians recommend individualized therapy