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In awake rats, analgesic amounts of a dermorphin analog stimulated respiration through central mu1 receptors, while higher, cataleptic amounts depressed breathing and blunted the response to carbon dioxide

Dihexa is orally bioavailable in animal models, with cognitive effects comparable to subcutaneous injection a property virtually absent among conventional neuropeptides that require intranasal or injectable delivery (PMID: 23055539)

10.1016/j.freeradbiomed.2015.05.036 226 ZhangJ

443, 633 Mirmira, R