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Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses

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New Guidance Suggests Most Patients Can Continue GLP-1 Medications Before Surgery 11/05/2024 In new guidelines, the American Society of Anesthesiologists (ASA) and other professional groups recommend that most patients using glucagon-like peptide-1 (GLP-1) receptor agonists can continue their medication regimen prior to elective surgery

doi: 10.1523/JNEUROSCI.2577-05.2005