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The original genetic-validation study used antisense oligonucleotide-mediated knockdown of NNMT in adipose tissue of mice on a high-fat diet, with whole-body and adipose-tissue metabolic endpoints measured against scrambled-oligonucleotide controls [2]
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They don't
If you try to cheat nature, it will backfire
Superdehydrated acetonitrile (10 mL, FUJIFILM) was added and stirred to completely dissolve DMAP and DSC, and then shaken for 24 h at room temperature using rocker shaker MR-1 (Biosan, Riga, Latvia)
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