Song, J., Kang, S
Two additional randomized clinical trials performed in GH patients treated with MMI alone did not show beneficial effects on thyroid function and peripheral manifestations of hyperthyroidism in patients given selenium compared with placebo ( Use of Selenium in GO Over the last few years, in addition to the most common treatment for the management of moderate-to-severe and active GO, namely high dose oral and intravenous glucocorticoids (GC), orbital irradiation and surgical procedures (58), other medications have been proven effective to various extents, including rituximab (59), the recently FDA-approved teprotumumab (60, 61), mycophenolate (62), and tocilizumab (63)
The minimum requirement seems to be the phenylethylamine skeleton: a benzene ring with a two-carbon side chain that terminates in an amino group
Beginners should start with 100 mcg of each peptide administered together before bed, 5 days per week
potentially fatal disturbances of cardiac conduction (widening of QRS), arrhythmias & seizures due to Na channel block (cardiac & CNS) Pharmacokinetics: PO, metabolized in the liver (P450 - 2D6)
