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Patients reporting intolerable symptoms at therapeutic doses should not proceed to higher doses, even if weight loss has plateaued

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First-Pass Metabolism The body has a process called "first-pass metabolism," where the liver and gut process substances before they reach the rest of the circulation

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Lipid metabolism and ferroptosis PUFAs contain diene-propyl hydrogens, especially arachidonic acid (AA) and adrenic acid (AdA), which are prone to react with ROS, leading to lipid peroxidation and cell death via ferroptosis [43] (Fig