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doi: 10.1038/s41586-025-09588-6 238 MichaudM.BalardyL.MoulisG.GaudinC.PeyrotC.VellasB.et al

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This Erastin-induced increase in autophagic flux is crucial because it directly enables ferritinophagy, a selective process that targets the iron-storage protein ferritin for degradation and is now recognized as a key driver of ferroptosis

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Renewed insights that we reviewed highlighted additional levels of regulation and a more diverse composition for the AR transcriptional complex