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Under normal conditions, Nrf2 is anchored in the cell cytoplasm by a repressor protein called Keap1
In addition, treatment of rhabdomyosarcoma cells with anti-IGF-IR mAb or IGF-IR/IR kinase inhibitor leads to increased activation of YES/Src family tyrosine kinase (SFK) [173]
doi: 10.1128/iai.65.8.3231-3238.1997
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