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Splitting the weekly dose into two smaller injections is sometimes done to reduce peak drug concentration and minimize GI side effects

The analysis of the SURPASS trials of tirzepatide revealed no association between weight reduction and gastrointestinal adverse events (229)

some autoinjectors require waiting for a second click) Withdraw the needle as instructed and release the skin fold if used Do not rub the injection site afterwards Dispose of the needle immediately in a sharps binnever reuse needles

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He also points to maximum allowable cost as a tool that remains underused across the industry, with many insurers still not applying it consistently or broadly enough