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the clinical significance in humans remains under investigation and is not yet established for retatrutide specifically [24] [25] Other class-associated cautions: Based on the broader GLP-1/GIP receptor agonist class, potential effects on gallbladder function and delayed gastric emptying are relevant considerations, though evidence specific to retatrutide is still emerging It is important to note that this evidence derives from early-phase trials conducted under controlled conditions with medical supervision

Previously, a Phase 3 clinical trial for the amustaline/glutathione (GSH) PR system was halted when antibodies specific to acridine (a by-product of amustaline) were found in patients

(2018) 14:e1007353

References Pohlandt, F

doi: 10.3390/genes10020153