Protein is the most satiating macronutrient, ii keep you full and satisfied for longer in part because protein increases the release of GLP-1 as well as another satiety influencig hormone (PYY or peptide YY)
Activation of the cytochrome P450 gene, CYP72C1, reduces the levels of active brassinosteroids in vivo
In fact, the opposite was discovered, and GLP-1R agonism was found to significantly reduce expression of hepatic Cyp2e1 independently of nutrient and ethanol intake, with the predictable consequence of higher serum ethanol levels after a fixed ethanol dose
That does not make it useless
This decrease in caloric consumption, combined with potential gastrointestinal side effects such as nausea, vomiting, and diarrhoea, may increase the risk of micronutrient deficiencies in certain individuals