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In parallel, mitochondrial fragmentation and stress signaling may alter the plasma membrane lipid microenvironment and reduce the efficiency of membrane protein insertion, thereby compromising OCTN2 anchoring and stability within membrane microdomains [114]

After this phase, most patients transition to a maintenance schedule, which uses less frequent dosing to help maintain the desired effect

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Brandfon S, Eylon A, Khanna D, Parmar MS

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