ZenaroEPietronigroEDella BiancaVPiacentinoGMarongiuLBuduiSet al
doi: 10.1038/s41571-019-0218-0
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Case reports of Melanotan II describe patients developing darkening of pre-existing moles and oral mucosa, priapism requiring emergency intervention, injection-site ulceration and pyoderma gangrenosum , renal infarction , and even a possible association with reports of ischemic strokeafter intranasal use
If results are promising, the programme moves to Phase 3: larger, global, randomised trials involving, dependent on the indication hundreds to sometimes even thousands of participants, designed to confirm efficacy and build a robust safety profile