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No confirmed tumor promotion has been documented in published animal studies, but the theoretical risk remains a cited contraindication for individuals with active cancer or a cancer history

[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Vukusic D., Zenko Sever A., Sever M., Drmic D., Milavic M., Sikiric S., Rasic D., Krezic I., Gojkovic S., Prtoric A., et al

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CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition

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