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N Engl J Med 2001;345:1583-93

(2023) 13:e064376

Eduardo Rivadeneyra Dominguez, Universidad Veracruzana, Mexico Updates Copyright 2023 Pujo, Fitriani, Ben Saad, Ghariani, Dghim, Mellouli, Burin, Mutricy, Houcke, Roujansky, Mansyur, Nkontcho, de Toffol, Ben Amara and Kallel

Key implications Study protocols must justify the relevance of each patient-reported outcome (PRO)

Calculated Dose The Food and Nutrition Board at the National Academies of Sciences, Engineering, and Medicine establishes the Tolerable Upper Intake Level for copper in adults at 10 mg/day