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[2] Opposing effects: Melatonin might counteract intended medication effects (e.g., reducing effectiveness of immunosuppressants)

Current pharmacological modulators targeting cGAS-STING signaling mainly include NiH, PEI-PDA@C-176 NPs, and FDL@TP, and these inhibitors have been confirmed to be effective in both in vitro experiments and murine arthritis (70, 71)