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Conversely, overexpression of SHBG reverses these effects, indicating that SHBG may mitigate IR by regulating glucose transporter expression via the cAMP/PKA/CREB1 signaling pathway [235]

Another study enrolled 273 patients with MDD who received various antidepressant treatments and assessed the severity of depression with the Hamilton Depression Scale-17 (HAMD) before and after 4 weeks of therapy (75)

Their mechanisms of action include activating GLUT4 and inhibiting NF-B

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