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Targeted proteomics methods such as selected reaction monitoring (SRM) and parallel reaction monitoring (PRM) offer increased sensitivity and specificity for biomarker validation and clinical implementation [61, 62]

If a drug makes someone feel unwell, reduced consumption of food or alcohol may reflect aversion rather than true changes in reward processing

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More specifically, chenodeoxycholic acid and deoxycholic acid directly reduce ZO-1 and OCLN tight junction proteins and disrupt the BBB [234]

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