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Diabetic patients should take this combination only under medical supervision

The failures to develop drugs to modulate other hormones reflect the complexity and redundancy of the biochemical signals that control our need to eat, says Linda Shapiro, the chief medical officer of Rhythm Pharmaceuticals, a company that specializes in weight-loss drugs for people who have genetic mutations that cause weight gain

Research suggests GIP activation improves insulin sensitivity in adipose tissue, may contribute to central nervous system appetite regulation beyond what GLP-1 provides, and appears to reduce some of the gastrointestinal side effects associated with GLP-1 agonism alone

Mounjaro additionally stimulates another gut hormone called GIP (glucose-dependent insulinotropic polypeptide), which might offer specific benefits for blood sugar control in some patients

GLP-1 Agonists : Promote significant weight loss (10%+), reduce appetite, and improve metabolic health