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NICE recommends GLP-1 receptor agonists for specific patient groups, typically those with inadequate glycaemic control despite other therapies, and often in the context of obesity

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4- Muscle Regeneration and Anti-Atrophy Protection Preclinical work 6 shows IGF-1 regulates matrix metalloproteinases (MMPs) and cytokines during tissue remodeling, ensuring balanced regeneration and reducing fibrotic scarring.IGF-1 also demonstrates protective effects against muscle atrophy by suppressing ubiquitin-proteasome pathways, helping preserve lean mass even during inactivity

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