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The IGF2/IR/IGF1R pathway in tumor cells and myofibroblasts mediates resistance to EGFR inhibition in cholangiocarcinoma

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Peroxynitrite, formed from NO and superoxide, contributes to mitochondrial dysfunction by initiating the formation of highly reactive radicals, including OH, CO 3 , and NO 2 , which target electron transport complexes and membrane lipids such as cardiolipin [53]

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