47 Most studies in patients on HD have shown benefits of B12 either on its own or extra benefit when added to other B vitamins (mostly folate)
The easiest solution
PubMed Sikiric, P., Seiwerth, S., Rucman, R., Turkovic, B., Rokotov, D.S., Brcic, L., Sever, M., Klicek, R., Radic, B., Drmic, D., Ilic, S., Kolenc, D
Fourth, if you want a measurable genetic baseline before titration not a population-average titration schedule with subjective tolerability adjustment over 812 weeks the Precision Peptide Genetic Test ($298 standalone or $99 as an add-on after your first month) maps 49 genes, 58 variants, and 14 pathways including 34 weight-management insights and the GIPR rs1800437 variant linked to differential GLP-1 response
3 Psychiatric safety of GLP-1 RAs The psychiatric safety of GLP-1 RAs continues to be examined across heterogeneous study populations and methodological approaches