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This results in a lower ability to promote receptor internalization compared with endogenous GLP-1, so it allows to have an increased GLP-1R expression on the cell surface, which translates in more robust insulinotropic properties, possibly explaining the enhanced insulin secretion (in both diabetic and not diabetic human islets), induced by TZP (48) ( Figure 1 )

N Acetyltransferases In humans, acetylation reactions are catalyzed by two acetyltransferase isoenzymes (NATs), acetyltransferase 1 (NAT1) and 2 (NAT2)

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