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Significance for Untargeted Metabolomics MoA Research This study illustrates the core value of metabolomics-based MoA characterisation: the activity difference between BSFL oil and its purified major fatty acid (C12:0) was only mechanistically interpretable through the lipid mediator metabolic landscape

4.3 Potential effects of gut metabolites on ferroptosis in OA 4.3.1 Gut metabolites inhibiting ferroptosis mechanisms 4.3.1.1 Tryptophan metabolites suppress ferroptosis via antioxidant mechanisms Tryptophan metabolites serve as pivotal mediators in host-microbiota interactions and are closely linked to systemic inflammatory and immune processes (Gaspar et al., 2025)

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It was reported that a horse spooked by a wind fan collapsed on Fimmel while performing one of his own stunts, but he emerged unscathed